With the recent changes in the world of veterinary feed directive (VFD) drugs, it is important to look back at all of the antibiotic oversight throughout the years. Back in 1996, Congress enacted the Animal Drug Availability Act (ADAA) establishing a new regulatory category for certain animal drugs in animal feed. In 2000 the FDA established VFD-related provisions and determined veterinary oversight was critical to assuring safe use. Now the recent Guidance #209 and Guidance #213 have established that the uses of these drugs must be considered necessary, and should include veterinary oversight. With the new veterinary oversight requirement, there are potential challenges for veterinarians working across state lines, and there is now a call for a legal definition of the Veterinary-Client-Patient Relationship. To learn more about the history and effects of government oversight on antibiotics, read here.